Glucocorticoid sensitizers Bag1 and Ppid are regulated by adolescent stress in a sex-dependent manner
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چکیده
منابع مشابه
Existence of cardiac PNMT mRNA in adult rats: elevation by stress in a glucocorticoid-dependent manner.
Phenylethanolamine N-methyltransferase (PNMT) is the enzyme that synthesizes epinephrine from norepinephrine. The aim of this study was to determine potential PNMT gene expression in the cardiac atria and ventricles of adult rats and to examine whether the gene expression of this enzyme is affected by immobilization stress. PNMT mRNA levels were detected in all four parts of the heart, with the...
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Discovering the mechanisms that underlie the origin of novel features represents a major frontier in developmental and evolutionary biology. Here we begin to characterize the role of the Hox gene Sex combs reduced (Scr) during the development and evolution of a morphologically novel trait: beetle horns. Beetle horns develop as epidermal outgrowths from the prothorax and/or head, and size and lo...
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Protein SUMOylation (SUMO is small ubiquitin-related modifier) is a dynamic process that is strictly regulated under physiological and pathological conditions. However, little is known about how various intra- or extra-cellular stimuli regulate expression levels of components in the SUMO system. SUMO isoforms SUMO2 and SUMO3 can rapidly convert to be conjugated in response to a variety of cellu...
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متن کاملRole of the hsp70 cochaperone BAG1 in glucocorticoid receptor function and stress-related diseases.
The article by Maeng et al. (1) reports on the role of the hsp70 cochaperone BAG1 in manic-like and depression-like behavioral phenotypes in mice. The authors discuss their results in connection with the established role of BAG1 in regulating the function of the glucocorticoid receptor (GR). They highlight this role of BAG1 because mania and depression are widely considered to be stress-related...
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ژورنال
عنوان ژورنال: Psychoneuroendocrinology
سال: 2013
ISSN: 0306-4530
DOI: 10.1016/j.psyneuen.2012.05.001